nkhani

Kutengera mafupa a aza-BODIPY, NIR1001 imaphatikiza magulu opereka ma elekitironi (mwachitsanzo, 4-N,N-diphenylaminophenyl) pa 2,6-positions, kupanga D-π-D yofananira1. Kapangidwe kameneka kamachepetsa kusiyana kwa HOMO-LUMO, kusuntha nsonga ya mayamwidwe kupitilira 1000 nm ndikukulitsa kusamutsa kwa intramolecular charge (ICT). Mu THF, NIR1001 ikuwonetsa gawo lalikulu la mafotoni awiri (TPA) a 37 GM, kuwongolera kawiri kuposa zotengera zachikhalidwe za BODIPY. Nthawi yake yosangalatsa ya moyo wa 1.2 ps imathandizira kusintha kosagwiritsa ntchito ma radiation, ndikupangitsa kukhala koyenera kwa Photodynamic therapy (PDT).

Kuwerengera kwa DFT kumawonetsa kuti njira yosinthira ndalama ya NIR1001 imachokera ku π-electron delocalization pakati pa opereka ndi omwe amavomereza. Kusintha kwa Methoxy kumapangitsanso kuyamwa kwa NIR pawindo la phototherapeutic (650-900 nm), kumapangitsa chidwi1. Poyerekeza ndi utoto wa AF wa Fudan University, NIR1001 imakhala ndi kulemera kochepa kwa mamolekyu (<500 Da) ndi 40% apamwamba kwambiri. Kusintha kwa carboxylation kumapangitsa kuti madzi asungunuke (cLogD=1.2), amachepetsa kutsatsa komwe sikunatchulidwe muzinthu zachilengedwe.

3. Ntchito Zachilengedwe
Mu bioimaging, hCG-conjugated probe hCG-NIR1001 imakwaniritsa kuyerekezera kwakukulu kwa ma follicles a ovarian ndi ma micro-metastases pansi pa 808 nm excitation. Ndi kuya kwa 3 cm mu NIR-II, imaposa ma probe a NIR-I katatu, ndikuchepetsa fluorescence yakumbuyo ndi 60%. Muchitsanzo cha kuvulala kwa mbewa, NIR1001 imawonetsa 85% yotengera aimpso, kuzindikira kuwonongeka kasanu ndi kamodzi kuposa kuwongolera kwa macromolecular.
Kwa PDT, NIR1001 imapanga mitundu ya okosijeni yokhazikika (ROS) pa 0.85 μmol/J pansi pa 1064 nm laser irradiation, mogwira mtima kupangitsa chotupa cell apoptosis. Liposome-encapsulated NIR1001 nanoparticles (NPs) imadziunjikira nthawi 7.2 m'matumbo kuposa utoto waulere, ndikuchepetsa zotsatira zomwe mukufuna.
4. Kuwunika kwa Industrial and Environmental Monitoring
M'mafakitale, NIR1001 imaphatikizidwa ku Juhang Technology's SupNIR-1000 analyzer yosankha zipatso, kuwunika kwamtundu wa nyama, komanso kukonza fodya. Imagwira ntchito mu 900-1700 nm, nthawi imodzi imayesa kuchuluka kwa shuga, chinyezi, ndi zotsalira za mankhwala ophera tizilombo mkati mwa masekondi 30 ndikulondola kwa ± (50ppm + 5%). M'magalimoto a CO2 masensa (ACDS-1001), NIR1001 imathandizira kuyang'anira nthawi yeniyeni ndi nthawi yoyankhira ya T90≤25s ndi moyo wa zaka 15.
Kuti muzindikire zachilengedwe, ma probe a NIR1001-functionalized amazindikira zitsulo zolemera m'madzi. Mu pH 6.5-8.0, fluorescence intensity linearly correlates ndi Hg²⁺ concentration (0.1-10 μM) yokhala ndi malire a 0.05 μM, njira zopambana za colorimetric ndi madongosolo awiri a kukula.
5. Zamakono Zamakono ndi Zamalonda
Qingdao Topwell Zidaamagwiritsa ntchito kaphatikizidwe kosalekeza kuti apange NIR1001 pa 99.5% chiyero, ndi 50 kg / batch mphamvu. Pogwiritsa ntchito ma microchannel reactors, nthawi ya Knoevenagel condensation imachepetsedwa kuchokera ku maola 12 mpaka mphindi 30, ndikuchepetsa kugwiritsa ntchito mphamvu ndi 60%. Mndandanda wa ISO 13485-certified NIR1001 umalamulira msika wa biomedical.